Lhx2 is expressed in the septum transversum mesenchyme that becomes an integral part of the liver and the formation of these cells is independent of functional Lhx2
Å Kolterud, E Wandzioch, L Carlsson - Gene expression patterns, 2004 - Elsevier
Liver development is based on reciprocal interactions between ventral foregut endoderm
and adjacent mesenchymal tissues. Targeted disruption of the LIM-homeobox gene Lhx2
has revealed that it is important for the expansion of the liver during embryonic development,
whereas it appears not to be involved in the induction of hepatic fate. It is not known whether
Lhx2 is expressed in the endodermal or mesenchymal portion of the liver, or if the cells
normally expressing Lhx2 are absent or present in the liver of Lhx2−/− embryos. To address …
and adjacent mesenchymal tissues. Targeted disruption of the LIM-homeobox gene Lhx2
has revealed that it is important for the expansion of the liver during embryonic development,
whereas it appears not to be involved in the induction of hepatic fate. It is not known whether
Lhx2 is expressed in the endodermal or mesenchymal portion of the liver, or if the cells
normally expressing Lhx2 are absent or present in the liver of Lhx2−/− embryos. To address …