Searching for common stem cells of the hepatic and hematopoietic systems in the human fetal liver: CD34+ cytokeratin 7/8+ cells express markers for stellate cells

DL Suskind, MO Muench - Journal of hepatology, 2004 - Elsevier
BACKGROUND/AIMS: The hematopoietic and hepatic systems are intertwined in the liver
during fetal life. Cells expressing the hematopoietic stem cell marker CD34 and cytokeratin
7/8 (CK7/8) are hypothesized to be common stem cells for the hematopoietic and hepatic
systems. Our aim was to determine if human fetal liver cells expressing CD34 and CK7/8
represent a common stem cell for both the hematopoietic and hepatic systems. METHODS:
CD34+ CK7/8+ cells from midgestation livers were analyzed for the expression of various …