Septum Transversum-Derived Mesothelium Gives Rise to Hepatic Stellate Cells and Perivascular Mesenchymal Cells in Developing Mouse Liver § Δ
The septum transversum mesenchyme (STM) signals to induce hepatogenesis from the
foregut endoderm. Hepatic stellate cells (HSCs) are sinusoidal pericytes assumed to
originate from the STM and participate in mesenchymal-epithelial interaction in embryonic
and adult livers. However, the developmental origin of HSCs remains elusive due to the lack
of markers for STM and HSCs. We previously identified submesothelial cells (SubMCs)
beneath mesothelial cells (MCs) as a potential precursor for HSCs in developing livers. In …
foregut endoderm. Hepatic stellate cells (HSCs) are sinusoidal pericytes assumed to
originate from the STM and participate in mesenchymal-epithelial interaction in embryonic
and adult livers. However, the developmental origin of HSCs remains elusive due to the lack
of markers for STM and HSCs. We previously identified submesothelial cells (SubMCs)
beneath mesothelial cells (MCs) as a potential precursor for HSCs in developing livers. In …