[HTML][HTML] Ectopic SOX9 mediates extracellular matrix deposition characteristic of organ fibrosis
KP Hanley, F Oakley, S Sugden, DI Wilson… - Journal of Biological …, 2008 - ASBMB
Appropriate temporospatial expression of the transcription factor SOX9 is important for
normal development of a wide range of organs. Here, we show that when SOX9 is
expressed ectopically, target genes become expressed that are associated with disease.
Histone deacetylase inhibitors in clinical trials for cancer therapy induced SOX9 expression
via enhanced recruitment of nuclear factor Y (NF-Y) to CCAAT elements in the SOX9
proximal promoter. The effect of histone deacetylase inhibitors could be elicited in cells that …
normal development of a wide range of organs. Here, we show that when SOX9 is
expressed ectopically, target genes become expressed that are associated with disease.
Histone deacetylase inhibitors in clinical trials for cancer therapy induced SOX9 expression
via enhanced recruitment of nuclear factor Y (NF-Y) to CCAAT elements in the SOX9
proximal promoter. The effect of histone deacetylase inhibitors could be elicited in cells that …