[HTML][HTML] Ubiquitous expression of the forkhead box M1B transgene accelerates proliferation of distinct pulmonary cell types following lung injury
VV Kalinichenko, GA Gusarova, Y Tan, IC Wang… - Journal of Biological …, 2003 - ASBMB
The delayed early transcription factor Forkhead Box M1B (FoxM1B) is expressed in
proliferating cells, but its expression is extinguished in cells undergoing terminal
differentiation. Liver regeneration studies with genetically altered mice that either
prematurely expressed FoxM1B in hepatocytes or contained a hepatocyte-specific deletion
of the Foxm1b allele demonstrated that FoxM1B is critical for regulating the expression of
cell cycle genes required for hepatocyte proliferation. Furthermore, preventing the decline in …
proliferating cells, but its expression is extinguished in cells undergoing terminal
differentiation. Liver regeneration studies with genetically altered mice that either
prematurely expressed FoxM1B in hepatocytes or contained a hepatocyte-specific deletion
of the Foxm1b allele demonstrated that FoxM1B is critical for regulating the expression of
cell cycle genes required for hepatocyte proliferation. Furthermore, preventing the decline in …