TGF-β/SMAD/GLI2 signaling axis in cancer progression and metastasis
D Javelaud, VI Alexaki, S Dennler, KS Mohammad… - Cancer research, 2011 - AACR
Cancer research, 2011•AACR
Abstract The Hedgehog (HH) and TGF-β signaling pathways represent essential regulators
of cell proliferation and differentiation during embryogenesis. Pathway deregulation is a
characteristic of various cancers. Recently, evidence for a convergence of these pathways at
the level of the GLI2 transcription factor in the context of tumor initiation and progression to
metastasis has emerged. This short review summarizes recent knowledge about GLI2
function and mechanisms of action downstream of TGF-β in cancer. Cancer Res; 71 (17); …
of cell proliferation and differentiation during embryogenesis. Pathway deregulation is a
characteristic of various cancers. Recently, evidence for a convergence of these pathways at
the level of the GLI2 transcription factor in the context of tumor initiation and progression to
metastasis has emerged. This short review summarizes recent knowledge about GLI2
function and mechanisms of action downstream of TGF-β in cancer. Cancer Res; 71 (17); …
Abstract
The Hedgehog (HH) and TGF-β signaling pathways represent essential regulators of cell proliferation and differentiation during embryogenesis. Pathway deregulation is a characteristic of various cancers. Recently, evidence for a convergence of these pathways at the level of the GLI2 transcription factor in the context of tumor initiation and progression to metastasis has emerged. This short review summarizes recent knowledge about GLI2 function and mechanisms of action downstream of TGF-β in cancer. Cancer Res; 71(17); 5606–10. ©2011 AACR.
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