[HTML][HTML] Factor H-related protein 4 activates complement by serving as a platform for the assembly of alternative pathway C3 convertase via its interaction with C3b …
M Hebecker, M Józsi - Journal of biological chemistry, 2012 - ASBMB
Human complement factor H-related protein (CFHR) 4 belongs to the factor H family of
plasma glycoproteins that are composed of short consensus repeat (SCR) domains.
Although factor H is a well known inhibitor of the alternative complement pathway, the
functions of the CFHR proteins are poorly understood. CFHR4 lacks SCRs homologous to
the complement inhibitory domains of factor H and, accordingly, has no significant
complement regulatory activities. We have previously shown that CFHR4 binds C-reactive …
plasma glycoproteins that are composed of short consensus repeat (SCR) domains.
Although factor H is a well known inhibitor of the alternative complement pathway, the
functions of the CFHR proteins are poorly understood. CFHR4 lacks SCRs homologous to
the complement inhibitory domains of factor H and, accordingly, has no significant
complement regulatory activities. We have previously shown that CFHR4 binds C-reactive …