[HTML][HTML] Stress-induced apoptosis associated with null mutation of ADAR1 RNA editing deaminase gene
Q Wang, M Miyakoda, W Yang, J Khillan… - Journal of Biological …, 2004 - ASBMB
One type of RNA editing involves the conversion of adenosine residues into inosine in
double-stranded RNA through the action of adenosine deaminases acting on RNA (ADAR).
A-to-I RNA editing of the coding sequence could result in synthesis of proteins not directly
encoded in the genome. ADAR edits also non-coding sequences of target RNAs, such as
introns and 3′-untranslated regions, which may affect splicing, translation, and mRNA
stability. Three mammalian ADAR gene family members (ADAR1-3) have been identified …
double-stranded RNA through the action of adenosine deaminases acting on RNA (ADAR).
A-to-I RNA editing of the coding sequence could result in synthesis of proteins not directly
encoded in the genome. ADAR edits also non-coding sequences of target RNAs, such as
introns and 3′-untranslated regions, which may affect splicing, translation, and mRNA
stability. Three mammalian ADAR gene family members (ADAR1-3) have been identified …