[PDF][PDF] High-resolution genomic profiling reveals gain of chromosome 14 as a predictor of poor outcome in ileal carcinoids
E Andersson, C Swärd, G Stenman… - Endocrine-related …, 2009 - researchgate.net
E Andersson, C Swärd, G Stenman, H Ahlman, O Nilsson
Endocrine-related cancer, 2009•researchgate.netIleal carcinoids are malignant neuroendocrine tumours of the small intestine. The aim of this
study was to obtain a high-resolution genomic profile of ileal carcinoids in order to define
genetic changes important for tumour initiation, progression, and survival. Forty-three
patients with ileal carcinoids were investigated by high-resolution array-based comparative
genomic hybridization. The average number of copy number alterations (CNAs) per tumour
was 7.1 (range 1-22), with losses being more common than gains (ratio 1.4).
study was to obtain a high-resolution genomic profile of ileal carcinoids in order to define
genetic changes important for tumour initiation, progression, and survival. Forty-three
patients with ileal carcinoids were investigated by high-resolution array-based comparative
genomic hybridization. The average number of copy number alterations (CNAs) per tumour
was 7.1 (range 1-22), with losses being more common than gains (ratio 1.4).
Abstract
Ileal carcinoids are malignant neuroendocrine tumours of the small intestine. The aim of this study was to obtain a high-resolution genomic profile of ileal carcinoids in order to define genetic changes important for tumour initiation, progression, and survival. Forty-three patients with ileal carcinoids were investigated by high-resolution array-based comparative genomic hybridization. The average number of copy number alterations (CNAs) per tumour was 7.1 (range 1-22), with losses being more common than gains (ratio 1.4).
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