[HTML][HTML] LFA-1 antagonism inhibits early infiltration of endogenous memory CD8 T cells into cardiac allografts and donor-reactive T cell priming
K Setoguchi, AD Schenk, D Ishii, Y Hattori… - American Journal of …, 2011 - Elsevier
Alloreactive memory T cells are present in virtually all transplant recipients due to prior
sensitization or heterologous immunity and mediate injury undermining graft outcome. In
mouse models, endogenous memory CD8 T cells infiltrate MHC-mismatched cardiac
allografts and produce IFN-γ in response to donor class I MHC within 24 h posttransplant.
The current studies analyzed the efficacy of anti-LFA-1 mAb to inhibit early CD8 T cell
cardiac allograft infiltration and activation. Anti-LFA-1 mAb given to C57BL/6 6 (H-2 b) …
sensitization or heterologous immunity and mediate injury undermining graft outcome. In
mouse models, endogenous memory CD8 T cells infiltrate MHC-mismatched cardiac
allografts and produce IFN-γ in response to donor class I MHC within 24 h posttransplant.
The current studies analyzed the efficacy of anti-LFA-1 mAb to inhibit early CD8 T cell
cardiac allograft infiltration and activation. Anti-LFA-1 mAb given to C57BL/6 6 (H-2 b) …