Phase I evaluation of recombinant tumor necrosis factor given in combination with recombinant interferon-gamma
JW Smith, WJ Urba, JW Clark, DI Longo… - Journal of …, 1991 - journals.lww.com
In light of in vitro and preclinical animal model data suggesting potential additive or
synergistic antitumor effects from the combined use of interferon-gamma (IFN-[gamma]) and
tumor necrosis factor-alpha (TNF-[alpha]), we conducted a phase I study employing
escalating doses of each agent in 36 patients with solid tumors to determine the maximum
tolerated dose (MTD). Patients were given an intramuscular (im) injection of IFN-[gamma],
followed 5 min later by an im injection of TNF-[alpha], each agent in different sites, every …
synergistic antitumor effects from the combined use of interferon-gamma (IFN-[gamma]) and
tumor necrosis factor-alpha (TNF-[alpha]), we conducted a phase I study employing
escalating doses of each agent in 36 patients with solid tumors to determine the maximum
tolerated dose (MTD). Patients were given an intramuscular (im) injection of IFN-[gamma],
followed 5 min later by an im injection of TNF-[alpha], each agent in different sites, every …