Clinical significance of GPR56, transglutaminase 2, and NF-κB in esophageal squamous cell carcinoma

T Kausar, R Sharma, MR Hasan, SC Tripathi… - Cancer …, 2011 - Taylor & Francis
T Kausar, R Sharma, MR Hasan, SC Tripathi, A Saraya, TK Chattopadhyay, SD Gupta…
Cancer investigation, 2011Taylor & Francis
Proteins do not operate as individual units, and components of intracellular canonical
pathways often cross talk in tumor genesis. We hypothesized that G-protein-coupled
receptor 56 (GPR56), transglutaminase (TG2), and nuclear factor-κB (NF-κB) may
collaborate in interconnected pathways and contribute to the aggressive behavior of
esophageal squamous cell carcinoma (ESCC). Immunohistochemical analysis of GPR56,
TG2, and NF-κB was carried out using ESCC tissue microarrays. Immunostaining of all the …
Proteins do not operate as individual units, and components of intracellular canonical pathways often cross talk in tumor genesis. We hypothesized that G-protein-coupled receptor 56 (GPR56), transglutaminase (TG2), and nuclear factor-κB (NF-κB) may collaborate in interconnected pathways and contribute to the aggressive behavior of esophageal squamous cell carcinoma (ESCC). Immunohistochemical analysis of GPR56, TG2, and NF-κB was carried out using ESCC tissue microarrays. Immunostaining of all the three proteins revealed a significant increase in their expression in ESCCs as compared with normal epithelia and correlated with their concomitant expression. A significant correlation between GPR56, TG2, and NF-κB was observed that correlated with nodal metastasis and tumor invasion in ESCCs.
Taylor & Francis Online