Hepatic lipase may act as a ligand in the uptake of artificial chylomicron remnant-like particles by isolated rat hepatocytes.
P Diard, MI Malewiak, D Lagrange, S Griglio - Biochemical Journal, 1994 - ncbi.nlm.nih.gov
P Diard, MI Malewiak, D Lagrange, S Griglio
Biochemical Journal, 1994•ncbi.nlm.nih.govActive and heat-inactivated hepatic lipase stimulated to a statistically comparable extent the
uptake of chylomicron remnant-like particles by isolated rat hepatocytes by 3-fold and 2.3-
fold respectively and, likewise, their binding to hepatic plasma membranes by 5-fold and 4-
fold respectively. Hepatic lipase may facilitate uptake of these particles, not only as a lipolytic
enzyme, but also as a ligand anchored to extracellular glycosaminoglycans.
uptake of chylomicron remnant-like particles by isolated rat hepatocytes by 3-fold and 2.3-
fold respectively and, likewise, their binding to hepatic plasma membranes by 5-fold and 4-
fold respectively. Hepatic lipase may facilitate uptake of these particles, not only as a lipolytic
enzyme, but also as a ligand anchored to extracellular glycosaminoglycans.
Abstract
Active and heat-inactivated hepatic lipase stimulated to a statistically comparable extent the uptake of chylomicron remnant-like particles by isolated rat hepatocytes by 3-fold and 2.3-fold respectively and, likewise, their binding to hepatic plasma membranes by 5-fold and 4-fold respectively. Hepatic lipase may facilitate uptake of these particles, not only as a lipolytic enzyme, but also as a ligand anchored to extracellular glycosaminoglycans.
ncbi.nlm.nih.gov