[HTML][HTML] Disruption of cholesterol 7α-hydroxylase gene in mice: II. Bile acid deficiency is overcome by induction of oxysterol 7α-hydroxylase

M Schwarz, EG Lund, KDR Setchell, HJ Kayden… - Journal of Biological …, 1996 - ASBMB
Past experiments and current paradigms of cholesterol homeostasis suggest that cholesterol
7α-hydroxylase plays a crucial role in sterol metabolism by controlling the conversion of
cholesterol into bile acids. Consistent with this conclusion, we show in the accompanying
paper that mice deficient in cholesterol 7α-hydroxylase (Cyp7−/− mice) exhibit a complex
phenotype consisting of abnormal lipid excretion, skin pathologies, and behavioral
irregularities (Ishibashi, S., Schwarz, M., Frykman, PK, Herz, J., and Russell, DW (1996) J …