MicroRNA regulation of core apoptosis pathways in cancer
RT Lima, S Busacca, GM Almeida, G Gaudino… - European journal of …, 2011 - Elsevier
European journal of cancer, 2011•Elsevier
Recent research has demonstrated that microRNAs (miRNAs) are key regulators of many
cell processes often deregulated in cancer, including apoptosis. Indeed, it is becoming clear
that many miRNAs are anti-apoptotic and mediate this effect by targeting pro-apoptotic
mRNAs or positive regulators of pro-apoptotic mRNAs. Conversely, many pro-apoptotic
miRNAs target anti-apoptotic mRNAs or their positive regulators. We have reviewed the
current knowledge in this area including evidence of miRNA involvement in cancer drug …
cell processes often deregulated in cancer, including apoptosis. Indeed, it is becoming clear
that many miRNAs are anti-apoptotic and mediate this effect by targeting pro-apoptotic
mRNAs or positive regulators of pro-apoptotic mRNAs. Conversely, many pro-apoptotic
miRNAs target anti-apoptotic mRNAs or their positive regulators. We have reviewed the
current knowledge in this area including evidence of miRNA involvement in cancer drug …
Recent research has demonstrated that microRNAs (miRNAs) are key regulators of many cell processes often deregulated in cancer, including apoptosis. Indeed, it is becoming clear that many miRNAs are anti-apoptotic and mediate this effect by targeting pro-apoptotic mRNAs or positive regulators of pro-apoptotic mRNAs. Conversely, many pro-apoptotic miRNAs target anti-apoptotic mRNAs or their positive regulators. We have reviewed the current knowledge in this area including evidence of miRNA involvement in cancer drug resistance.
Elsevier