[HTML][HTML] Prognostic significance of, and gene and microRNA expression signatures associated with, CEBPA mutations in cytogenetically normal acute myeloid …
Journal of clinical oncology, 2008•ncbi.nlm.nih.gov
Purpose To evaluate the prognostic significance of CEBPA mutations in the context of
established molecular markers in cytogenetically normal (CN) acute myeloid leukemia
(AML) and gain biologic insights into leukemogenesis of the CN-AML molecular high-risk
subset (FLT3 internal tandem duplication [ITD] positive and/or NPM1 wild type) that has a
significantly higher incidence of CEBPA mutations than the molecular low-risk subset (FLT3-
ITD negative and NPM1 mutated).
established molecular markers in cytogenetically normal (CN) acute myeloid leukemia
(AML) and gain biologic insights into leukemogenesis of the CN-AML molecular high-risk
subset (FLT3 internal tandem duplication [ITD] positive and/or NPM1 wild type) that has a
significantly higher incidence of CEBPA mutations than the molecular low-risk subset (FLT3-
ITD negative and NPM1 mutated).
Abstract
Purpose
To evaluate the prognostic significance of CEBPA mutations in the context of established molecular markers in cytogenetically normal (CN) acute myeloid leukemia (AML) and gain biologic insights into leukemogenesis of the CN-AML molecular high-risk subset (FLT3 internal tandem duplication [ITD] positive and/or NPM1 wild type) that has a significantly higher incidence of CEBPA mutations than the molecular low-risk subset (FLT3-ITD negative and NPM1 mutated).
ncbi.nlm.nih.gov