Take five—BACE and the γ‐secretase quartet conduct Alzheimer's amyloid β‐peptide generation
C Haass - The EMBO journal, 2004 - embopress.org
C Haass
The EMBO journal, 2004•embopress.orgIn 1959, Dave Brubeck and Paul Desmond revolutionized modern jazz music by composing
their unforgettable Take Five in 5/4, one of the most defiant time signatures in all music. Of
similar revolutionary importance for biomedical and basic biochemical research is the
identification of the minimal set of genes required to obtain a deadly time bomb ticking in all
of us: Alzheimer's disease. It now appears that one needs to Take Five genes to produce a
deadly peptide by a proteolytic mechanism, which paradoxically is otherwise of pivotal …
their unforgettable Take Five in 5/4, one of the most defiant time signatures in all music. Of
similar revolutionary importance for biomedical and basic biochemical research is the
identification of the minimal set of genes required to obtain a deadly time bomb ticking in all
of us: Alzheimer's disease. It now appears that one needs to Take Five genes to produce a
deadly peptide by a proteolytic mechanism, which paradoxically is otherwise of pivotal …
In 1959, Dave Brubeck and Paul Desmond revolutionized modern jazz music by composing their unforgettable Take Five in 5/4, one of the most defiant time signatures in all music. Of similar revolutionary importance for biomedical and basic biochemical research is the identification of the minimal set of genes required to obtain a deadly time bomb ticking in all of us: Alzheimer's disease. It now appears that one needs to Take Five genes to produce a deadly peptide by a proteolytic mechanism, which paradoxically is otherwise of pivotal importance for development and cell fate decisions.
embopress.org