Squamous cell carcinomas and increased apoptosis in skin with inhibited Rel/nuclear factor-κB signaling
M Hogerlinden, BL Rozell, L Ährlund-Richter… - Cancer research, 1999 - AACR
M Hogerlinden, BL Rozell, L Ährlund-Richter, R ToftgÅrd
Cancer research, 1999•AACRThe Rel/nuclear factor-κB (Rel/NF-κB) transcription factors have been implicated previously
in control of apoptosis, cell proliferation, and oncogenesis. Here we show that selective
inhibition of Rel/NF-κB signaling in murine skin, by targeted overexpression of a super-
repressor form of IκB-α, results in an increased basal frequency of apoptotic cells and the
spontaneous development of squamous cell carcinomas. Presence of hyperplasia and hair
follicle degeneration demonstrate an important role for Rel/NF-κB signaling in normal …
in control of apoptosis, cell proliferation, and oncogenesis. Here we show that selective
inhibition of Rel/NF-κB signaling in murine skin, by targeted overexpression of a super-
repressor form of IκB-α, results in an increased basal frequency of apoptotic cells and the
spontaneous development of squamous cell carcinomas. Presence of hyperplasia and hair
follicle degeneration demonstrate an important role for Rel/NF-κB signaling in normal …
Abstract
The Rel/nuclear factor-κB (Rel/NF-κB) transcription factors have been implicated previously in control of apoptosis, cell proliferation, and oncogenesis. Here we show that selective inhibition of Rel/NF-κB signaling in murine skin, by targeted overexpression of a super-repressor form of IκB-α, results in an increased basal frequency of apoptotic cells and the spontaneous development of squamous cell carcinomas. Presence of hyperplasia and hair follicle degeneration demonstrate an important role for Rel/NF-κB signaling in normal epidermal development and homeostasis. Transgenic skin, in addition, showed an enhanced sensitivity to UV-induced apoptosis. These data suggest an involvement of the Rel/NF-κB signaling pathway in apoptosis and cancer development of the skin.
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