Correlation of cellular immunity with human papillomavirus 16 status and outcome in patients with advanced oropharyngeal cancer
Objective To determine whether the favorable outcome associated with human
papillomavirus (HPV) 16–positive oropharyngeal cancer is related to a patient's adaptive
immunity. Setting Academic medical center. Patients Forty-seven of 66 previously untreated
patients (6 of 20 patients with stage III and 41 of 46 with stage IV cancer) in a prospective
clinical trial of chemoradiotherapy. Intervention All patients were treated with a single course
of neoadjuvant chemotherapy followed by either surgery (for nonresponders) or …
papillomavirus (HPV) 16–positive oropharyngeal cancer is related to a patient's adaptive
immunity. Setting Academic medical center. Patients Forty-seven of 66 previously untreated
patients (6 of 20 patients with stage III and 41 of 46 with stage IV cancer) in a prospective
clinical trial of chemoradiotherapy. Intervention All patients were treated with a single course
of neoadjuvant chemotherapy followed by either surgery (for nonresponders) or …