[HTML][HTML] Irx4 forms an inhibitory complex with the vitamin D and retinoic X receptors to regulate cardiac chamber-specific slow MyHC3Expression
GF Wang, W Nikovits, ZZ Bao, FE Stockdale - Journal of Biological …, 2001 - ASBMB
The slow myosin heavy chain 3 gene (slow MyHC3) is restricted in its expression to the atrial
chambers of the heart. Understanding its regulation provides a basis for determination of the
mechanisms controlling chamber-specific gene expression in heart development. The
observed chamber distribution results from repression of slow MyHC3 gene expression in
the ventricles. A binding site, the vitamin D response element (VDRE), for a heterodimer of
vitamin D receptor (VDR) and retinoic X receptor α (RXRα) within the slow MyHC3 promoter …
chambers of the heart. Understanding its regulation provides a basis for determination of the
mechanisms controlling chamber-specific gene expression in heart development. The
observed chamber distribution results from repression of slow MyHC3 gene expression in
the ventricles. A binding site, the vitamin D response element (VDRE), for a heterodimer of
vitamin D receptor (VDR) and retinoic X receptor α (RXRα) within the slow MyHC3 promoter …