[HTML][HTML] Functional characterization of human RSK4, a new 90-kDa ribosomal S6 kinase, reveals constitutive activation in most cell types
BA Dummler, C Hauge, J Silber, HG Yntema… - Journal of Biological …, 2005 - ASBMB
The 90-kDa ribosomal S6 kinases (RSK1–3) are important mediators of growth factor
stimulation of cellular proliferation, survival, and differentiation and are activated via
coordinated phosphorylation by ERK and 3-phosphoinositide-dependent protein kinase-1
(PDK1). Here we performed the functional characterization of a predicted new human RSK
homologue, RSK4. We showed that RSK4 is a predominantly cytosolic protein with very low
expression and several characteristics of the RSK family kinases, including the presence of …
stimulation of cellular proliferation, survival, and differentiation and are activated via
coordinated phosphorylation by ERK and 3-phosphoinositide-dependent protein kinase-1
(PDK1). Here we performed the functional characterization of a predicted new human RSK
homologue, RSK4. We showed that RSK4 is a predominantly cytosolic protein with very low
expression and several characteristics of the RSK family kinases, including the presence of …