Matriptase-2 (TMPRSS6) is directly up-regulated by hypoxia inducible factor-1: identification of a hypoxia-responsive element in the TMPRSS6 promoter region
E Maurer, M Gütschow, M Stirnberg - Biological chemistry, 2012 - degruyter.com
E Maurer, M Gütschow, M Stirnberg
Biological chemistry, 2012•degruyter.comThe type II transmembrane serine protease matriptase-2 (TMPRSS6) down-regulates the
expression of hepcidin, the main regulator of systemic iron homeostasis, and increases in
this way iron plasma levels. Matriptase-2 is up-regulated under hypoxic conditions,
providing a new link between hypoxia signaling and iron homeostasis. In this study, we have
characterized the TMPRSS6 promoter region and identified a functional hypoxia-responsive
element (HRE). Mutations of the hypoxia inducible factor (HIF)-binding site located within the …
expression of hepcidin, the main regulator of systemic iron homeostasis, and increases in
this way iron plasma levels. Matriptase-2 is up-regulated under hypoxic conditions,
providing a new link between hypoxia signaling and iron homeostasis. In this study, we have
characterized the TMPRSS6 promoter region and identified a functional hypoxia-responsive
element (HRE). Mutations of the hypoxia inducible factor (HIF)-binding site located within the …
Abstract
The type II transmembrane serine protease matriptase-2 (TMPRSS6) down-regulates the expression of hepcidin, the main regulator of systemic iron homeostasis, and increases in this way iron plasma levels. Matriptase-2 is up-regulated under hypoxic conditions, providing a new link between hypoxia signaling and iron homeostasis. In this study, we have characterized the TMPRSS6 promoter region and identified a functional hypoxia-responsive element (HRE). Mutations of the hypoxia inducible factor (HIF)-binding site located within the HRE abrogate HIF-1α-dependent induction of TMPRSS6 expression. The action of HIF-1α on TMPRSS6 promoter activity reveals a new regulative element for the suppression of hepcidin synthesis.
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