[HTML][HTML] The role of hepatocyte hemojuvelin in the regulation of bone morphogenic protein-6 and hepcidin expression in vivo
AS Zhang, J Gao, DD Koeberl, CA Enns - Journal of Biological Chemistry, 2010 - ASBMB
Both hemojuvelin (HJV) and bone morphogenic protein-6 (BMP6) are essential for hepcidin
expression. Hepcidin is the key peptide hormone in iron homeostasis, and is secreted
predominantly by hepatocytes. HJV expression is detected in hepatocytes, as well as in
skeletal and heart muscle. HJV binds BMP6 and increases hepcidin expression presumably
by acting as a BMP co-receptor. We characterized the role of hepatocyte HJV in the
regulation of BMP6 and hepcidin expression. In HJV-null (Hjv−/−) mice that have severe iron …
expression. Hepcidin is the key peptide hormone in iron homeostasis, and is secreted
predominantly by hepatocytes. HJV expression is detected in hepatocytes, as well as in
skeletal and heart muscle. HJV binds BMP6 and increases hepcidin expression presumably
by acting as a BMP co-receptor. We characterized the role of hepatocyte HJV in the
regulation of BMP6 and hepcidin expression. In HJV-null (Hjv−/−) mice that have severe iron …