A new MALDI-TOF-based assay for monitoring JAK2 V617F mutation level in patients undergoing allogeneic stem cell transplantation (allo SCT) for classic …
M Koren-Michowitz, A Shimoni, A Vivante… - Leukemia Research, 2008 - Elsevier
JAK2 V617F mutation is found in a high proportion of MPD patients. We developed a
quantitative assay for the detection of the JAK2 mutation and demonstrated its clinical utility
in MPD patients who underwent SCT. Sixty percent of the patients were JAK2 V617F
positive prior to the SCT (mean mutation levels 74%, range 16–98%). After the procedure,
the mutation levels progressively decreased and were in correlation with the donor–
recipient chimerism status (r= 0.97, p< 0.001). At a median follow up of 16 months (range 2 …
quantitative assay for the detection of the JAK2 mutation and demonstrated its clinical utility
in MPD patients who underwent SCT. Sixty percent of the patients were JAK2 V617F
positive prior to the SCT (mean mutation levels 74%, range 16–98%). After the procedure,
the mutation levels progressively decreased and were in correlation with the donor–
recipient chimerism status (r= 0.97, p< 0.001). At a median follow up of 16 months (range 2 …