Cushing's syndrome

J Newell-Price, X Bertagna, AB Grossman, LK Nieman - The Lancet, 2006 - thelancet.com
J Newell-Price, X Bertagna, AB Grossman, LK Nieman
The Lancet, 2006thelancet.com
Cushing's syndrome results from lengthy and inappropriate exposure to excessive
glucocorticoids. Untreated, it has significant morbidity and mortality. The syndrome remains
a challenge to diagnose and manage. Here, we review the current understanding of
pathogenesis, clinical features, diagnostic, and differential diagnostic approaches. We
provide diagnostic algorithms and recommendations for management.
Summary
Cushing's syndrome results from lengthy and inappropriate exposure to excessive glucocorticoids. Untreated, it has significant morbidity and mortality. The syndrome remains a challenge to diagnose and manage. Here, we review the current understanding of pathogenesis, clinical features, diagnostic, and differential diagnostic approaches. We provide diagnostic algorithms and recommendations for management.
thelancet.com