Increased expression of Toll-like receptor 3 in decidual natural killer cells of patients with unexplained recurrent spontaneous miscarriage
SH Bao, W Shuai, J Tong, L Wang, P Chen… - European Journal of …, 2012 - Elsevier
OBJECTIVE: To investigate whether the expression of Toll-like receptor 3 (TLR3) in decidual
natural killer (dNK) cells plays a role in the pathogenesis of unexplained recurrent
spontaneous miscarriage (URSM). STUDY DESIGN: NK cells were isolated from human
decidual tissue through magnetic cell sorting and analyzed for phenotypes through flow
cytometry. TLR3 expression in dNK cells was detected by quantitative reverse-transcriptase
polymerase chain reaction and western blotting. The cytotoxicity of dNK was detected using …
natural killer (dNK) cells plays a role in the pathogenesis of unexplained recurrent
spontaneous miscarriage (URSM). STUDY DESIGN: NK cells were isolated from human
decidual tissue through magnetic cell sorting and analyzed for phenotypes through flow
cytometry. TLR3 expression in dNK cells was detected by quantitative reverse-transcriptase
polymerase chain reaction and western blotting. The cytotoxicity of dNK was detected using …