Locally generated angiotensin II (AngII) may be involved in the pathogenic mechanisms of
chronic renal diseases. Renal expression of AngII and other components of the renin-
angiotensin system (RAS) were analyzed by immunohistochemistry and Western blot in a
model of chronic progressive nephropathy induced by inhibition of nitric oxide synthesis.
Renal injury was evaluated by histology and albumin excretion. Systemic RAS status was
evaluated through plasma renin activity (PRA) and plasma AngII concentration. In addition …