Activation of mitogen-activated protein kinases by vascular endothelial growth factor and basic fibroblast growth factor in capillary endothelial cells is inhibited by the …
G d'Angelo, I Struman, J Martial… - Proceedings of the …, 1995 - National Acad Sciences
G d'Angelo, I Struman, J Martial, RI Weiner
Proceedings of the National Academy of Sciences, 1995•National Acad SciencesA number of factors both stimulating and inhibiting angiogenesis have been described. In
the current work, we demonstrate that the angiogenic factor vascular endothelial growth
factor (VEGF) activates mitogen-activated protein kinase (MAPK) as has been previously
shown for basic fibroblast growth factor. The antiagiogenic factor 16-kDa N-terminal
fragment of human prolactin inhibits activation of MAPK distal to autophosphorylation of the
putative VEGF receptor, Flk-1, and phospholipase C-gamma. These data show that …
the current work, we demonstrate that the angiogenic factor vascular endothelial growth
factor (VEGF) activates mitogen-activated protein kinase (MAPK) as has been previously
shown for basic fibroblast growth factor. The antiagiogenic factor 16-kDa N-terminal
fragment of human prolactin inhibits activation of MAPK distal to autophosphorylation of the
putative VEGF receptor, Flk-1, and phospholipase C-gamma. These data show that …
A number of factors both stimulating and inhibiting angiogenesis have been described. In the current work, we demonstrate that the angiogenic factor vascular endothelial growth factor (VEGF) activates mitogen-activated protein kinase (MAPK) as has been previously shown for basic fibroblast growth factor. The antiagiogenic factor 16-kDa N-terminal fragment of human prolactin inhibits activation of MAPK distal to autophosphorylation of the putative VEGF receptor, Flk-1, and phospholipase C-gamma. These data show that activation and inhibition of MAPK may play a central role in the control of angiogenesis.
National Acad Sciences