TGF-β signaling in aortic aneurysm: another round of controversy
F Lin, X Yang - Journal of Genetics and Genomics, 2010 - Elsevier
Aortic aneurysm (AA) is a common health problem with high mortality and no effective drugs.
Transforming growth factor-β (TGF-β) superfamily members regulate various cellular
processes, and TGF-β signaling has key roles in development, tissue homeostasis, and
diseases. Interest in the role of TGF-β signaling in the pathogenesis of AAs has recently
emerged, particularly since genetic studies demonstrated an association between gene
mutations in components of TGF-β signaling and AAs. However, paradoxical discoveries …
Transforming growth factor-β (TGF-β) superfamily members regulate various cellular
processes, and TGF-β signaling has key roles in development, tissue homeostasis, and
diseases. Interest in the role of TGF-β signaling in the pathogenesis of AAs has recently
emerged, particularly since genetic studies demonstrated an association between gene
mutations in components of TGF-β signaling and AAs. However, paradoxical discoveries …