Evolution of substrate specificities in the P-type ATPase superfamily
KB Axelsen, MG Palmgren - Journal of molecular evolution, 1998 - Springer
KB Axelsen, MG Palmgren
Journal of molecular evolution, 1998•SpringerP-type ATPases make up a large superfamily of ATP-driven pumps involved in the
transmembrane transport of charged substrates. We have performed an analysis of
conserved core sequences in 159 P-type ATPases. The various ATPases group together in
five major branches according to substrate specificity, and not according to the evolutionary
relationship of the parental species, indicating that invention of new substrate specificities is
accompanied by abrupt changes in the rate of sequence evolution. A hitherto-unrecognized …
transmembrane transport of charged substrates. We have performed an analysis of
conserved core sequences in 159 P-type ATPases. The various ATPases group together in
five major branches according to substrate specificity, and not according to the evolutionary
relationship of the parental species, indicating that invention of new substrate specificities is
accompanied by abrupt changes in the rate of sequence evolution. A hitherto-unrecognized …
Abstract
P-type ATPases make up a large superfamily of ATP-driven pumps involved in the transmembrane transport of charged substrates. We have performed an analysis of conserved core sequences in 159 P-type ATPases. The various ATPases group together in five major branches according to substrate specificity, and not according to the evolutionary relationship of the parental species, indicating that invention of new substrate specificities is accompanied by abrupt changes in the rate of sequence evolution. A hitherto-unrecognized family of P-type ATPases has been identified that is expected to be represented in all the major phyla of eukarya.
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