Wnts are important for various developmental and oncogenic processes. Here we show that
Wnt signaling functions at synapses in hippocampal neurons. Tetanic stimulations induce N-
methyl-d-aspartate receptor-dependent synaptic Wnt3a release, nuclear β-catenin
accumulations, and the activation of Wnt target genes. Suppression of Wnt signaling impairs
long term potentiation. Conversely, activation of Wnt signaling facilitates long term
potentiation. These findings suggest that Wnt signaling plays a critical role in regulating …