[HTML][HTML] Interleukin 33 as a mechanically responsive cytokine secreted by living cells
Interleukin 33 (IL-33), a member of the Interleukin 1 cytokine family, is implicated in
numerous human inflammatory diseases such as asthma, atherosclerosis, and rheumatoid
arthritis. Despite its pathophysiologic importance, fundamental questions regarding the
basic biology of IL-33 remain. Nuclear localization and lack of an export signal sequence
are consistent with the view of IL-33 as a nuclear factor with the ability to repress RNA
transcription. However, signaling via the transmembrane receptor ST2 and documented …
numerous human inflammatory diseases such as asthma, atherosclerosis, and rheumatoid
arthritis. Despite its pathophysiologic importance, fundamental questions regarding the
basic biology of IL-33 remain. Nuclear localization and lack of an export signal sequence
are consistent with the view of IL-33 as a nuclear factor with the ability to repress RNA
transcription. However, signaling via the transmembrane receptor ST2 and documented …