[HTML][HTML] Regulation of tyrosine hydroxylase mRNA stability by protein-binding, pyrimidine-rich sequence in the 3′-untranslated region
WR Paulding, MF Czyzyk-Krzeska - Journal of Biological Chemistry, 1999 - ASBMB
The stability of mRNA for tyrosine hydroxylase (TH), the rate-limiting enzyme in
catecholamine synthesis, is regulated by oxygen tension in the pheochromocytoma-derived
PC12 cell line. We previously identified a pyrimidine-rich 27-base-long protein-binding
sequence in the 3′-untranslated region of TH mRNA that is associated with hypoxia-
inducible formation of a ribonucleoprotein complex (hypoxia-inducible protein-binding site
(HIPBS)). In this study, we show that HIPBS is an mRNA stabilizing element necessary for …
catecholamine synthesis, is regulated by oxygen tension in the pheochromocytoma-derived
PC12 cell line. We previously identified a pyrimidine-rich 27-base-long protein-binding
sequence in the 3′-untranslated region of TH mRNA that is associated with hypoxia-
inducible formation of a ribonucleoprotein complex (hypoxia-inducible protein-binding site
(HIPBS)). In this study, we show that HIPBS is an mRNA stabilizing element necessary for …