Hypoxia—a key regulatory factor in tumour growth
AL Harris - Nature reviews cancer, 2002 - nature.com
Nature reviews cancer, 2002•nature.com
Cells undergo a variety of biological responses when placed in hypoxic conditions,
including activation of signalling pathways that regulate proliferation, angiogenesis and
death. Cancer cells have adapted these pathways, allowing tumours to survive and even
grow under hypoxic conditions, and tumour hypoxia is associated with poor prognosis and
resistance to radiation therapy. Many elements of the hypoxia-response pathway are
therefore good candidates for therapeutic targeting.
including activation of signalling pathways that regulate proliferation, angiogenesis and
death. Cancer cells have adapted these pathways, allowing tumours to survive and even
grow under hypoxic conditions, and tumour hypoxia is associated with poor prognosis and
resistance to radiation therapy. Many elements of the hypoxia-response pathway are
therefore good candidates for therapeutic targeting.
Abstract
Cells undergo a variety of biological responses when placed in hypoxic conditions, including activation of signalling pathways that regulate proliferation, angiogenesis and death. Cancer cells have adapted these pathways, allowing tumours to survive and even grow under hypoxic conditions, and tumour hypoxia is associated with poor prognosis and resistance to radiation therapy. Many elements of the hypoxia-response pathway are therefore good candidates for therapeutic targeting.
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