When mammalian cell cultures or mice are exposed to ionizing radiation in survivable or
lethal amounts, novel mass components are found in the histone H2A region of two-
dimensional gels. Collectively referred to as γ, these components are formed in vivo by
several procedures that introduce double-stranded breaks into DNA. γ-Components, which
appeared to be the only major novel components detected by mass or 32 PO 4 incorporation
on acetic acid-urea-Triton X-100-acetic acid-urea-cetyltrimethylammonium bromide or SDS …