Poorly controlled diabetes is associated with vascular complications including renal failure,
peripheral vascular disease, neuropathy, blindness, amputations, coronary artery disease,
and stroke. Multiple large clinical trials have shown the benefits of intensifying glycemic
control in preventing or delaying microvascular complications. These trials, however,
consistently report significantly higher rates of hypoglycemia a Division of Endocrinology,
Metabolism & Lipid Research, Department of Medicine, Washington