[HTML][HTML] The Myotonic Dystrophy Type 2 Protein ZNF9 Is Part of an ITAF Complex That Promotes Cap-independent Translation* S

VR Gerbasi, AJ Link - Molecular & Cellular Proteomics, 2007 - ASBMB
The 5′-untranslated region of the ornithine decarboxylase (ODC) mRNA contains an
internal ribosomal entry site (IRES). Mutational analysis of the ODC IRES has led to the
identification of sequences necessary for cap-independent translation of the ODC mRNA. To
discover novel IRES trans-acting factors (ITAFs), we performed a proteomics screen for
proteins that regulate ODC translation using the wild-type ODC mRNA and a mutant version
with an inactive IRES. We identified two RNA-binding proteins that associate with the wild …