Human memory CTL response specific for influenza A virus is broad and multispecific

C Gianfrani, C Oseroff, J Sidney, RW Chesnut… - Human immunology, 2000 - Elsevier
Class I restricted cytotoxic T-lymphocyte (CTL) responses are thought to be focused against
few immunodominant epitopes. In humans, an often quoted example of such narrow focus is
the influenza A (FLU) matrix 58-66 specific memory CTL activity, detectable in HLA-A2
individuals as a result of natural infection. Herein, we analyzed the repertoire of memory,
FLU-specific CTLs in A2 and A11 positive individuals. Eighteen A2. 1 binding peptides,
derived from the FLU-Puerto Rico/8/34 (PR8) isolate, elicited CTL activity in A2. 1/Kb …