Usefulness and optimization of mouse models of allergic airway disease

FD Finkelman, M Wills-Karp - Journal of Allergy and Clinical …, 2008 - jacionline.org
The usefulness of animal models for studying human asthma has been heavily debated. 1-
12 Although mouse models in particular provide several potential advantages for studying
allergic airway disease (Table I), 13 these advantages disappear if these models differ from
the human disease to such an extent that lessons learned from the mouse model are
misleading. In this regard investigators who think mouse models are useful have
summarized important similarities between experimental mouse allergic airway disease and …