Genomic imprinting, growth control and the allocation of nutritional resources: consequences for postnatal life
M Charalambous, ST da Rocha… - Current Opinion in …, 2007 - journals.lww.com
M Charalambous, ST da Rocha, AC Ferguson-Smith
Current Opinion in Endocrinology, Diabetes and Obesity, 2007•journals.lww.comThe mono-allelic behaviour and sensitivity to changes in regional epigenetic states renders
imprinted genes adaptable and vulnerable; in all cases, their perturbed dosage can
compromise prenatal and/or postnatal control of nutritional resources. This finding has
implications for understanding the relationships between prenatal events and diseases later
in life.
imprinted genes adaptable and vulnerable; in all cases, their perturbed dosage can
compromise prenatal and/or postnatal control of nutritional resources. This finding has
implications for understanding the relationships between prenatal events and diseases later
in life.
Summary
The mono-allelic behaviour and sensitivity to changes in regional epigenetic states renders imprinted genes adaptable and vulnerable; in all cases, their perturbed dosage can compromise prenatal and/or postnatal control of nutritional resources. This finding has implications for understanding the relationships between prenatal events and diseases later in life.
Lippincott Williams & Wilkins