[HTML][HTML] Mitogen-activated protein kinase pathway is involved in the differentiation of muscle cells
E Gredinger, AN Gerber, Y Tamir, SJ Tapscott… - Journal of Biological …, 1998 - ASBMB
The differentiation of muscle cells is controlled by the MyoD family of transcription factors.
This family is regulated by extracellular growth factors that transmit largely unknown signals
into the cells. Here we show that the activity of extracellular signal-regulated protein kinase
(ERK), a kinase that is part of the mitogen-activated protein kinase (MAPK) cascade, is low
in myoblasts and is induced with the onset of terminal differentiation of C2 cells. ERK activity
is also induced in fibroblasts that were modified to express MyoD, but not in the parental …
This family is regulated by extracellular growth factors that transmit largely unknown signals
into the cells. Here we show that the activity of extracellular signal-regulated protein kinase
(ERK), a kinase that is part of the mitogen-activated protein kinase (MAPK) cascade, is low
in myoblasts and is induced with the onset of terminal differentiation of C2 cells. ERK activity
is also induced in fibroblasts that were modified to express MyoD, but not in the parental …