Muscular dystrophies
I Nishino, E Ozawa - Current opinion in neurology, 2002 - journals.lww.com
I Nishino, E Ozawa
Current opinion in neurology, 2002•journals.lww.comSeveral possible mechanisms causing muscular dystrophy were discussed. Defects in
extracellular molecules have more significant effects resulting mainly in congenital muscular
dystrophy, while intracellular molecular defects show milder effect on the phenotype. These
hypotheses may provide a new paradigm in understanding the pathomechanism of
muscular dystrophies.
extracellular molecules have more significant effects resulting mainly in congenital muscular
dystrophy, while intracellular molecular defects show milder effect on the phenotype. These
hypotheses may provide a new paradigm in understanding the pathomechanism of
muscular dystrophies.
Summary
Several possible mechanisms causing muscular dystrophy were discussed. Defects in extracellular molecules have more significant effects resulting mainly in congenital muscular dystrophy, while intracellular molecular defects show milder effect on the phenotype. These hypotheses may provide a new paradigm in understanding the pathomechanism of muscular dystrophies.
Lippincott Williams & Wilkins