β-cell growth and regeneration: replication is only part of the story
S Bonner-Weir, WC Li, L Ouziel-Yahalom, L Guo… - Diabetes, 2010 - Am Diabetes Assoc
S Bonner-Weir, WC Li, L Ouziel-Yahalom, L Guo, GC Weir, A Sharma
Diabetes, 2010•Am Diabetes AssocFIG. 1. Neogenesis in mouse pancreas. A: The metaplastic ducts seen in the zinc-treated
metallothionen. TGF-transgenic mice have 6% insulin (red, white arrows) cells and some
amylase (green, yellow arrow) cells. Tissue from study reported in (37); the background in
the red channel was enhanced to see the context of the ducts. Magnification bar 100 m. B:
After partial (70–80%) pancreatectomy in adult mice, insulin (blue) cells “budding” from
proliferating ductules labeled with E-cadherin (red) are found in well-defined areas termed …
metallothionen. TGF-transgenic mice have 6% insulin (red, white arrows) cells and some
amylase (green, yellow arrow) cells. Tissue from study reported in (37); the background in
the red channel was enhanced to see the context of the ducts. Magnification bar 100 m. B:
After partial (70–80%) pancreatectomy in adult mice, insulin (blue) cells “budding” from
proliferating ductules labeled with E-cadherin (red) are found in well-defined areas termed …
FIG. 1. Neogenesis in mouse pancreas. A: The metaplastic ducts seen in the zinc-treated metallothionen. TGF-transgenic mice have 6% insulin (red, white arrows) cells and some amylase (green, yellow arrow) cells. Tissue from study reported in (37); the background in the red channel was enhanced to see the context of the ducts. Magnification bar 100 m. B: After partial (70–80%) pancreatectomy in adult mice, insulin (blue) cells “budding” from proliferating ductules labeled with E-cadherin (red) are found in well-defined areas termed foci of regeneration that further differentiate into new lobes of pancreas (40). Magnification bar 50 m.(A high-quality digital representation of this figure is available in the online issue.)
Am Diabetes Assoc