Apoptotic body engulfment by hepatic stellate cells promotes their survival by the JAK/STAT and Akt/NF-κB-dependent pathways
JX Jiang, K Mikami, S Venugopal, Y Li, NJ Török - Journal of hepatology, 2009 - Elsevier
BACKGROUND/AIMS: We have previously shown that phagocytosis of apoptotic bodies
(AB) by hepatic stellate cells (HSC) is profibrogenic. As HSC survival is central to the
progression of liver fibrosis, our goal was to investigate if phagocytosis induces HSC
survival. METHODS: Apoptosis of phagocytosing HSC was studied in the presence of known
apoptotic agents. The JAK/STAT-and PI3K/Akt-dependent pathways, NF-κB activation and
expression of the anti-apoptotic proteins Mcl-1 and A1 were evaluated. Apoptosis was …
(AB) by hepatic stellate cells (HSC) is profibrogenic. As HSC survival is central to the
progression of liver fibrosis, our goal was to investigate if phagocytosis induces HSC
survival. METHODS: Apoptosis of phagocytosing HSC was studied in the presence of known
apoptotic agents. The JAK/STAT-and PI3K/Akt-dependent pathways, NF-κB activation and
expression of the anti-apoptotic proteins Mcl-1 and A1 were evaluated. Apoptosis was …