Fibrosis is a common pathological process for the majority of liver diseases which in a
significant minority of patients leads to end-stage cirrhosis and/or hepatocellular carcinoma.
Data emerging from small rodent models of chronic liver disease have demonstrated that
fibrotic extracellular matrix can be remodelled and near-normal hepatic architecture
regenerated upon cessation of injury. Moreover, regression of liver fibrosis in these model
systems can be stimulated with drugs that target the activities of fibrogenic hepatic stellate …