Long–Term Interleukin 10 Therapy in Chronic Hepatitis C Patients Has A Proviral and Anti–Inflammatory Effect
DR Nelson, Z Tu, C Soldevila-Pico, M Abdelmalek… - Hepatology, 2003 - journals.lww.com
An imbalance in Th1 and Th2 cytokine production is implicated in disease progression of
HCV. Our aim was to determine the effect of IL–10 administration in patients with HCV–
related liver disease. Thirty patients with advanced fibrosis who had failed antiviral therapy
were enrolled in a 12–month treatment regimen with SQ IL–10 given daily or thrice weekly.
Liver biopsies were performed before and after therapy. Serum and PBMC were collected
for HCV RNA, ALT, and functional T–cell analysis. IL–10 led to significant improvement in …
HCV. Our aim was to determine the effect of IL–10 administration in patients with HCV–
related liver disease. Thirty patients with advanced fibrosis who had failed antiviral therapy
were enrolled in a 12–month treatment regimen with SQ IL–10 given daily or thrice weekly.
Liver biopsies were performed before and after therapy. Serum and PBMC were collected
for HCV RNA, ALT, and functional T–cell analysis. IL–10 led to significant improvement in …