Vascular endothelial growth factor secreted by replicating hepatocytes induces sinusoidal endothelial cell proliferation during regeneration after partial hepatectomy in …
H Shimizu, M Miyazaki, Y Wakabayashi… - Journal of …, 2001 - Elsevier
Background: The aim of this study was to investigate regulatory mechanisms of sinusoidal
endothelial cell (SEC) proliferation after hepatectomy in rats. Methods: We investigated
expressions of vascular endothelial cell growth factor (VEGF) and its receptors, flt-1 and
KDR/flk-1, in regenerating liver after 70% hepatectomy. Proliferation of both hepatocytes and
SECs was also monitored by evaluating the proliferating cell nuclear antigen (PCNA)
labeling index. Furthermore, VEGF production by cultured hepatocytes isolated at different …
endothelial cell (SEC) proliferation after hepatectomy in rats. Methods: We investigated
expressions of vascular endothelial cell growth factor (VEGF) and its receptors, flt-1 and
KDR/flk-1, in regenerating liver after 70% hepatectomy. Proliferation of both hepatocytes and
SECs was also monitored by evaluating the proliferating cell nuclear antigen (PCNA)
labeling index. Furthermore, VEGF production by cultured hepatocytes isolated at different …