OV6+ tumor-initiating cells contribute to tumor progression and invasion in human hepatocellular carcinoma
W Yang, C Wang, Y Lin, Q Liu, L Yu, L Tang… - Journal of …, 2012 - Elsevier
BACKGROUND & AIMS: Accumulating evidence suggests the involvement of tumor-
initiating cells (T-ICs) in cancer genesis, but whether liver T-ICs contribute to HCC invasion
and metastasis remains unclear. METHODS: OV6+ T-ICs were isolated from SMMC7721
and HuH7 cell lines by magnetic sorting. Characteristics of T-ICs were assessed by in vitro
and mouse xenograft assays. Expression of OV6 was determined by immunostaining in
specimens from 218 HCC patients, and Kaplan–Meier survival analysis was used to …
initiating cells (T-ICs) in cancer genesis, but whether liver T-ICs contribute to HCC invasion
and metastasis remains unclear. METHODS: OV6+ T-ICs were isolated from SMMC7721
and HuH7 cell lines by magnetic sorting. Characteristics of T-ICs were assessed by in vitro
and mouse xenograft assays. Expression of OV6 was determined by immunostaining in
specimens from 218 HCC patients, and Kaplan–Meier survival analysis was used to …