Metastasis results from preexisting variant cells within a malignant tumor
IJ Fidler, ML Kripke - Science, 1977 - science.org
IJ Fidler, ML Kripke
Science, 1977•science.orgClones derived in vitro from a parent culture of murine malignant melanoma cells varied
greatly in their ability to produce metastatic colonies in the lungs upon intravenous
inoculation into syngeneic mice. This suggests that the parent tumor is heterogeneous and
that highly metastatic tumor cell variants preexist in the parental population.
greatly in their ability to produce metastatic colonies in the lungs upon intravenous
inoculation into syngeneic mice. This suggests that the parent tumor is heterogeneous and
that highly metastatic tumor cell variants preexist in the parental population.
Clones derived in vitro from a parent culture of murine malignant melanoma cells varied greatly in their ability to produce metastatic colonies in the lungs upon intravenous inoculation into syngeneic mice. This suggests that the parent tumor is heterogeneous and that highly metastatic tumor cell variants preexist in the parental population.
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