Transcriptomic profiling reveals hepatic stem-like gene signatures and interplay of miR-200c and epithelial-mesenchymal transition in intrahepatic …
N Oishi, MR Kumar, S Roessler, J Ji, M Forgues… - Hepatology, 2012 - journals.lww.com
Intrahepatic cholangiocellular carcinoma (ICC) is the second most common type of primary
liver cancer. However, its tumor heterogeneity and molecular characteristics are largely
unknown. In this study, we conducted transcriptomic profiling of 23 ICC and combined
hepatocellular cholangiocarcinoma tumor specimens from Asian patients using Affymetrix
messenger RNA (mRNA) and NanoString microRNA microarrays to search for unique gene
signatures linked to tumor subtypes and patient prognosis. We validated the signatures in an …
liver cancer. However, its tumor heterogeneity and molecular characteristics are largely
unknown. In this study, we conducted transcriptomic profiling of 23 ICC and combined
hepatocellular cholangiocarcinoma tumor specimens from Asian patients using Affymetrix
messenger RNA (mRNA) and NanoString microRNA microarrays to search for unique gene
signatures linked to tumor subtypes and patient prognosis. We validated the signatures in an …